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Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. Sci Rep 2015 Jun 11;5:11123

Date

06/13/2015

Pubmed ID

26068176

Pubmed Central ID

PMC4464075

DOI

10.1038/srep11123

Scopus ID

2-s2.0-84931281934   20 Citations

Abstract

Dietary fats and sodium are both palatable and are hypothesized to synergistically contribute to ingestive behavior and thereby obesity. Contrary to this hypothesis, C57BL/6J mice fed a 45% high fat diet exhibited weight gain that was inhibited by increased dietary sodium content. This suppressive effect of dietary sodium upon weight gain was mediated specifically through a reduction in digestive efficiency, with no effects on food intake behavior, physical activity, or resting metabolism. Replacement of circulating angiotensin II levels reversed the effects of high dietary sodium to suppress digestive efficiency. While the AT1 receptor antagonist losartan had no effect in mice fed low sodium, the AT2 receptor antagonist PD-123,319 suppressed digestive efficiency. Correspondingly, genetic deletion of the AT2 receptor in FVB/NCrl mice resulted in suppressed digestive efficiency even on a standard chow diet. Together these data underscore the importance of digestive efficiency in the pathogenesis of obesity, and implicate dietary sodium, the renin-angiotensin system, and the AT2 receptor in the control of digestive efficiency regardless of mouse strain or macronutrient composition of the diet. These findings highlight the need for greater understanding of nutrient absorption control physiology, and prompt more uniform assessment of digestive efficiency in animal studies of energy balance.

Author List

Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL

Author

Justin L. Grobe PhD Associate Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dietary Fats
Digestion
Gene Deletion
Imidazoles
Intestinal Absorption
Losartan
Male
Mice
Pyridines
Receptor, Angiotensin, Type 2
Renin-Angiotensin System
Sodium Chloride, Dietary