Faculty Collaboration Database

Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections. J Pediatr 1983 Apr;102(4):623-7

Date

04/01/1983

Pubmed ID

6339708

DOI

10.1016/s0022-3476(83)80207-8

Scopus ID

2-s2.0-0020519445 (requires institutional sign-in at Scopus site)   32 Citations

Abstract

Forty-nine ambulatory children between 2-1/2 and 12 years of age with acute, clinically uncomplicated urinary tract infections caused by susceptible organisms were randomized to receive a single dose of amoxicillin based on weight or a 10-day course of amoxicillin therapy (conventional therapy). Patients receiving single doses of amoxicillin had a cure rate of 63%, which compares unfavorably with the cure rate of 92% in patients given conventional therapy. A failure of single-dose therapy predicted underlying radiologic abnormalities with a sensitivity of 60% and a specificity of 58%, making it a poor screening test for detecting those patients at risk for renal parenchymal damage. The antibody-coated bacteria assay had no predictive value in separating upper and lower tract disease, although it may predict underlying radiologic abnormalities. The data indicate that the response to single-dose amoxicillin therapy fails to separate upper from lower tract disease reliably and has a limited role in predicting response to conventional antimicrobial therapy.

Author List

Avner ED, Ingelfinger JR, Herrin JT, Link DA, Marcus E, Tolkoff-Rubin NE, Russell-Getz L, Rubin RH

Author

Ellis D. Avner MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acute Disease
Adolescent
Amoxicillin
Antibody-Coated Bacteria Test, Urinary
Child
Child, Preschool
Clinical Trials as Topic
Escherichia coli Infections
Female
Humans
Male
Random Allocation
Risk
Urinary Tract Infections