Faculty Collaboration Database

The effect of donor-specific transfusions on rat heart allograft survival. Transplantation 1984 Dec;38(6):575-8

Date

12/01/1984

Pubmed ID

6390816

DOI

10.1097/00007890-198412000-00004

Scopus ID

2-s2.0-0021738963 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

A rat heart allograft model employing donor-specific transfusions (DSTs) was used to investigate several questions relevant to their clinical usage. The effects of varying blood storage duration (stored vs. fresh), number and timing of DSTs as well as use of concomitant azathioprine and cyclosporine (CsA) were assessed in terms of allograft survival and recipient sensitization. A comparison of stored and fresh-blood DSTs revealed that blood stored for up to 5 weeks was as effective as fresh blood and that a 2-week storage was optimal. Increased storage appeared to be associated with decreased sensitization. Multiple DSTs were more effective than a single DST and the peak effect appeared after six. Transfusions given at the time of transplantation were ineffective. The addition of concomitant (preoperative) azathioprine or CsA resulted in a further decrease in sensitization but also resulted in a dose-dependent diminution of the transfusion effect.

Author List

Johnson CP, Munda R, Alexander JW, Balakrishnan K, Blanton M

Author

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Azathioprine
Blood Transfusion
Cyclosporins
Graft Survival
Heart Transplantation
Male
Organ Preservation
Rats
Rats, Inbred Strains