Faculty Collaboration Database

Dietary mutagen exposure and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2007 Apr;16(4):655-61

Date

04/10/2007

Pubmed ID

17416754

Pubmed Central ID

PMC1892159

DOI

10.1158/1055-9965.EPI-06-0993

Scopus ID

2-s2.0-34247473918 (requires institutional sign-in at Scopus site)   50 Citations

Abstract

To investigate the association between dietary exposure to food mutagens and risk of pancreatic cancer, we conducted a hospital-based case-control study at the University of Texas M. D. Anderson Cancer Center during June 2002 to May 2006. A total of 626 cases and 530 noncancer controls were frequency matched for race, sex and age (+/-5 years). Dietary exposure information was collected via personal interview using a meat preparation questionnaire. A significantly greater portion of the cases than controls showed a preference to well-done pork, bacon, grilled chicken, and pan-fried chicken, but not to hamburger and steak. Cases had a higher daily intake of food mutagens and mutagenicity activity (revertants per gram of daily meat intake) than controls did. The daily intakes of 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP), as well as the mutagenic activity, were significant predictors for pancreatic cancer (P = 0.008, 0.031, and 0.029, respectively) with adjustment of other confounders. A significant trend of elevated cancer risk with increasing DiMeIQx intake was observed in quintile analysis (P(trend) = 0.024). A higher intake of dietary mutagens (those in the two top quintiles) was associated with a 2-fold increased risk of pancreatic cancer among those without a family history of cancer but not among those with a family history of cancer. A possible synergistic effect of dietary mutagen exposure and smoking was observed among individuals with the highest level of exposure (top 10%) to PhIP and BaP, P(interaction) = 0.09 and 0.099, respectively. These data support the hypothesis that dietary mutagen exposure alone and in interaction with other factors contribute to the development of pancreatic cancer.

Author List

Li D, Day RS, Bondy ML, Sinha R, Nguyen NT, Evans DB, Abbruzzese JL, Hassan MM

Author

Douglas B. Evans MD Chair, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Analysis of Variance
Benzo(a)pyrene
Case-Control Studies
Cooking
Diet
Female
Humans
Male
Meat
Middle Aged
Mutagens
Pancreatic Neoplasms
Quinoxalines
ROC Curve
Risk Factors
Smoking
Statistics, Nonparametric
Surveys and Questionnaires
Texas