Faculty Collaboration Database

Measuring health-related quality of life in population-based studies of coronary heart disease: comparing six generic indexes and a disease-specific proxy score. Qual Life Res 2009 Nov;18(9):1239-47

Date

09/18/2009

Pubmed ID

19760103

Pubmed Central ID

PMC2759459

DOI

10.1007/s11136-009-9533-8

Scopus ID

2-s2.0-70349950513 (requires institutional sign-in at Scopus site)   41 Citations

Abstract

PURPOSE: To compare HRQoL differences with CHD in generic indexes and a proxy CVD-specific score in a nationally representative sample of U.S. adults.

METHODS: The National Health Measurement Study, a cross-sectional random-digit-dialed telephone survey of adults aged 35-89, administered the EQ-5D, QWB-SA, HUI2, HUI3, SF-36v2 (yielding PCS, MCS, and SF-6D), and HALex. Analyses compared 3,350 without CHD (group 1), 265 with CHD not taking chest pain medication (group 2), and 218 with CHD currently taking chest pain medication (group 3), with and without adjustment for demographic variables and comorbidities. Data on 154 patients from heart failure clinics were used to construct a proxy score utilizing generic items probing CVD symptoms.

RESULTS: Mean scores differed between CHD groups for all indexes with and without adjustment (P < 0.0001 for all except MCS P = 0.018). Unadjusted group 3 versus 1 differences were about three times larger than for group 2 versus 1. Standardized differences for the proxy score were similar to those for generic indexes, and were about 1.0 for all except MCS for group 3 versus 1.

CONCLUSIONS: Generic indexes capture differences in HRQoL in population-based studies of CHD similarly to a score constructed from questions probing CVD-specific symptoms.

Author List

Garster NC, Palta M, Sweitzer NK, Kaplan RM, Fryback DG

Author

Noelle C. Garster MD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Coronary Disease
Female
Health Status
Humans
Interviews as Topic
Male
Middle Aged
Proxy
Quality of Life
Surveys and Questionnaires
United States