Candida dubliniensis Pneumonia: A Case Report and Review of Literature. Mycopathologia 2016 Oct;181(9-10):765-8
Date
06/28/2016Pubmed ID
27342836DOI
10.1007/s11046-016-0032-5Scopus ID
2-s2.0-84976292926 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Candida dubliniensis is an uncommon species of Candida which has been implicated in fungal pneumonia only very rarely. We present the case of a 75-year-old man with laryngeal cancer undergoing chemotherapy on broad-spectrum antibiotics and tuberculosis therapy with blood and endotracheal cultures positive for C. dubliniensis. Subsequent autopsy was performed with postmortem lung cultures positive for C. dubliniensis and lung histopathology demonstrating an invasive fungal infection. Molecular analysis of the lung tissue confirmed the identity of the fungi as C. dubliniensis. Since its discovery as a pathogen in the oral cavities of HIV-positive patients, C. dubliniensis has been identified in a wide spectrum of clinical scenarios and anatomic locations but manifests only rarely as pneumonia. This report represents a novel case of C. dubliniensis pneumonia confirmed by culture, histopathology, and molecular identification.
Author List
Petty LA, Gallan AJ, Detrick JA, Ridgway JP, Mueller J, Pisano JAuthor
Alexander J. Gallan MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAutopsy
Candida
Candidiasis
DNA, Fungal
Fatal Outcome
Histocytochemistry
Humans
Laryngeal Neoplasms
Lung
Male
Microbiological Techniques
Pneumonia
RNA, Ribosomal
Sequence Analysis, DNA
