Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection. J Infect Dis 2019 Oct 22;220(11):1843-1847
Date
07/25/2019Pubmed ID
31332447Pubmed Central ID
PMC7325325DOI
10.1093/infdis/jiz371Scopus ID
2-s2.0-85073665266 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γ and interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.
Author List
Claeys TA, Rosas Mejia O, Marshall S, Jarzembowski JA, Hayes D Jr, Hull NM, Liyanage NPM, Chun RH, Sulman CG, Huppler AR, Robinson RTAuthors
Robert H. Chun MD Professor in the Otolaryngology department at Medical College of WisconsinAnna H. Huppler MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Jason A. Jarzembowski MD, PhD Sr Associate Dean, CEO CSG, Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentBlood
Cell Differentiation
Child
Child, Preschool
Cohort Studies
Female
Humans
Infant
Infant, Newborn
Interferon-gamma
Interleukin-17
Lymph Nodes
Male
Mycobacterium Infections
Nontuberculous Mycobacteria
Th1 Cells
Th17 Cells
