Altered beta-band functional connectivity may be related to 'performance slowing' in good outcome aneurysmal subarachnoid patients. Neurosci Lett 2019 Apr 23;699:64-70
Date
02/04/2019Pubmed ID
30711525DOI
10.1016/j.neulet.2019.01.053Scopus ID
2-s2.0-85061010288 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Recent evidence suggests that good neurological outcome in subarachnoid hemorrhage (SAH) does not equate to good neuropsychological and cognitive outcome. These individuals continue to face cognitive difficulties in tasks involving mental flexibility, short-term memory and attention, resulting in decreased independence in daily living and reduced ability to return to work. In the current study, we examined the functional connectivity profiles using magnetoencephalography (MEG) in SAH patients, versus controls, during a visual short-term memory, 1-back, task. Our results found that a global measure of MEG-based phase synchrony in the beta band (15-30 Hz), derived from a time window during correct recognition, significantly differentiated the controls from the patients. During correct recognition, the connectivity patterns in the controls were characterized by inter-hemispheric parieto-frontal connections, involving the posterior parietal cortex, while patients appeared to recruit an entirely different network of regions, involving the anterior frontal and temporal regions. Reduced beta-band synchrony during recognition was associated with overall poorer performance, demonstrated as lower accuracy and slower reaction times in patients, but not in controls. This differentiation between groups suggests an important and distinct role of beta-band phase synchronization, perhaps for memory retrieval, associated with good performance. Performance slowing, short-term memory and attention deficits in these patients may be attributed to the impaired beta-band connectivity among prefrontal regions and the posterior parietal cortex.
Author List
Shah-Basak PP, Dunkley BT, Ye AX, Wong S, da Costa L, Pang EWAuthor
Priyanka P. Shah PhD Assistant Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Case-Control StudiesFemale
Frontal Lobe
Humans
Magnetoencephalography
Male
Memory, Short-Term
Middle Aged
Neural Pathways
Parietal Lobe
Subarachnoid Hemorrhage
Temporal Lobe
