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Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats. Diabetes Res Clin Pract 2009 Jan;83(1):e27-30

Date

12/20/2008

Pubmed ID

19095325

Pubmed Central ID

PMC2652566

DOI

10.1016/j.diabres.2008.11.003

Scopus ID

2-s2.0-57949111356 (requires institutional sign-in at Scopus site)   95 Citations

Abstract

Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans. SGLT1 and SGLT2 levels in diabetic obese rats were 1.6 (P<0.03) and 4.8 (P<0.002) folds higher than age-matched leans, respectively.

Author List

Tabatabai NM, Sharma M, Blumenthal SS, Petering DH

Author

Samuel S. Blumenthal MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Diabetes Mellitus, Experimental
Kidney
Male
Rats
Rats, Zucker
Reverse Transcriptase Polymerase Chain Reaction
Sodium-Glucose Transport Proteins
Sodium-Glucose Transporter 1
Sodium-Glucose Transporter 2