Measuring estrogens in women, men, and children: Recent advances 2012-2017. Clin Biochem 2018 Dec;62:11-23
Date
05/26/2018Pubmed ID
29800559DOI
10.1016/j.clinbiochem.2018.05.014Scopus ID
2-s2.0-85049096586 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
The measurement of estrogens is important for diagnosing and monitoring the health of women, men, and children. For example, for postmenopausal women or women undergoing treatment for breast cancer with aromatase inhibitors, the measurement of extremely low concentrations of estrogens in serum, especially estradiol, is problematic but essential for proper medical care. Achieving superb analytical sensitivity and specificity has been and continues to be a challenge for the clinical laboratory, but is a challenge that is being taken seriously. Focusing on publications from 2012 to 2017, this review will provide an overview of recent research in the development of methods to accurately and precisely measure estrogens, including a variety of estrogen metabolites. Additionally, the latest in clinical research involving estrogen measurement in women, men, and children will be presented to provide an update on the association of estrogens with diseases or conditions such as breast cancer, precocious puberty, infertility, and pregnancy. This research update will provide context as to why estrogen measurement is important and why laboratories are working hard to support the recommendations made by the Endocrine Society regarding estrogen measurement.
Author List
Smy L, Straseski JAAuthor
Laura Smy PhD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersBreast Neoplasms
Child
Endocrine Glands
Endocrine System Diseases
Endocrinology
Estradiol
Estrogens
Evidence-Based Medicine
Female
Humans
Infertility, Female
Infertility, Male
Male
Practice Guidelines as Topic
Pregnancy
Pregnancy Complications
Prognosis
Prostatic Neoplasms
Societies, Scientific
