Faculty Collaboration Database

Improved survival among sickle cell kidney transplant recipients in the recent era. Nephrol Dial Transplant 2013 Apr;28(4):1039-46

Date

01/25/2013

Pubmed ID

23345624

DOI

10.1093/ndt/gfs585

Scopus ID

2-s2.0-84875982878 (requires institutional sign-in at Scopus site)   40 Citations

Abstract

BACKGROUND: Studies from older cohorts of kidney recipients have observed that recipients with sickle cell disease (SCD) have lower patient survival compared with age- and race-matched controls. We examined whether survival has improved among SCD recipients in the current era.

METHODS: Using Organ Procurement and Transplantation Network/United Network for Organ Sharing data, all black/African-American kidney recipients were stratified according to transplant year into an early (1988-99) and recent era (2000-11). Patient and allograft survival among SCD recipients and those with other diagnoses were compared (early era: SCD n = 67, others n = 20 694; recent era: SCD n = 106, others n = 34 428). A secondary-matched cohort analysis compared patient and allograft survival between SCD recipients matched to recipients with other diagnoses based on recipient and donor age, gender and donor type (deceased versus living).

RESULTS: Patient survival at 6 years was lower among SCD recipients in the early era compared with other diagnoses (55.7 versus 78.0%; P < 0.001). Six-year patient survival among sickle cell recipients improved in the recent era (69.8%; P versus early era = 0.04), although still trended toward lower survival compared with other diagnoses (80.0%; P = 0.07). Multivariate Cox proportional hazard models revealed an increased mortality risk with SCD in both eras [early: hazard ratio (HR) = 3.12; 95% confidence interval (CI): 2.15-4.54; recent: HR: 2.03; 95% CI: 1.31-3.16]. Patient survival among matched SCD recipients in the recent era was comparable to diabetic recipients (SCD: 73.1%, diabetes: 74.1%; P = 0.44).

CONCLUSIONS: Patient survival has improved among contemporary sickle cell recipients compared with an earlier cohort and is comparable to a matched cohort of diabetic kidney recipients. Appropriately selected SCD patients may receive kidney transplants with reasonable survival outcome.

Author List

Huang E, Parke C, Mehrnia A, Kamgar M, Pham PT, Danovitch G, Bunnapradist S

Author

Mandana Kamgar MD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anemia, Sickle Cell
Case-Control Studies
Female
Follow-Up Studies
Graft Rejection
Graft Survival
Humans
Kidney Failure, Chronic
Kidney Transplantation
Male
Middle Aged
Prognosis
Survival Rate