Kidney failure requiring kidney transplantation after pancreas transplant alone. Clin Transpl 2013:45-52
Date
01/01/2013Pubmed ID
25095491Scopus ID
2-s2.0-84906954437 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Pancreas transplant alone (PTA) is usually performed in type 1 diabetic patients with preserved renal function to correct severe metabolic complications. One of the major concerns is renal failure after PTA. Here, we reported the cumulative incidence of kidney failure requiring kidney transplantation (KF/KT) among PTA recipients in the United States. Using the Organ Procurement Transplant Network/ United Network for Organ Sharing database, all primary adult PTA recipients with estimated baseline glomerular filtration rate (by the Modification of Diet in Renal Disease equation) >or=60 mL/min/1.73m2 were selected (n=1085). KF/ KT after PTA was defined as: wait-listing for or receiving a kidney alone (KA) or simultaneous pancreas kidney (SPK) transplant. The median follow-up time was 1185 days (25-75%: 524-2183). Ten years post PTA, 120 (11.1%) patients developed KF/KT; of those, 70 (6.5%) subsequently received a KA/SPK transplant (56 received KA and 14 received SPK) and 50 (4.6%) recipients were listed without receiving a transplant. The cumulative incidence of KF/KT after PTA at 1, 3, and 5 years after PTA was 0.3, 2.5, and 9.7%, respectively. In conclusion, KF/KT after PTA was not uncommon (9.7% at 5 years), and prospective PTA recipients should be aware of the risks of kidney failure after transplantation.
Author List
Nata N, Huang E, Kamgar M, Leeaphorn N, Mehrnia A, Kalantar-Zadeh K, Bunnapradist SAuthor
Mandana Kamgar MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultDiabetes Mellitus, Type 1
Female
Humans
Incidence
Kidney Failure, Chronic
Kidney Transplantation
Male
Middle Aged
Pancreas Transplantation
Registries
Retrospective Studies
Risk Factors
United States
