GB virus C viremia is associated with higher levels of double-negative T cells and lower T-cell activation in HIV-infected individuals receiving antiretroviral therapy. J Infect Dis 2012 Nov;206(9):1469-72
Date
08/29/2012Pubmed ID
22927453Pubmed Central ID
PMC3466998DOI
10.1093/infdis/jis515Scopus ID
2-s2.0-84867562525 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Double-negative T cells (DNTCs; ie, CD3(+)CD4(-)CD8(-) T cells) play a role in limiting chronic immune activation. GB virus C (GBV-C) infection is associated with reduced T-cell activation in human immunodeficiency virus (HIV)-infected individuals. T-cell activation and DNTCs were measured in HIV-infected subjects with a nondetectable HIV load. GBV-C-viremic subjects had significantly reduced CD4(+) and CD8(+) T-cell activation (P = .003 and .034, respectively) and significantly increased DNTCs (P = .038), compared with nonviremic subjects. GBV-C load correlated with DNTC percentage (P = .004). Thus, GBV-C infection is associated with an increase in DNTCs, which may contribute to reduced immune activation during HIV infection.
Author List
Bhattarai N, Rydze RT, Chivero ET, Stapleton JTAuthor
Robert Rydze MD Assistant Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antiretroviral Therapy, Highly ActiveCD3 Complex
CD4 Antigens
CD4-Positive T-Lymphocytes
CD8 Antigens
CD8-Positive T-Lymphocytes
GB virus C
HIV Infections
Hepatitis, Viral, Human
Humans
Lymphocyte Activation
Male
Middle Aged
T-Lymphocyte Subsets
Viremia
