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Donor-specific blood transfusions with stored and fresh blood in a rat heart allograft model. J Surg Res 1984 Jun;36(6):532-4

Date

06/01/1984

Pubmed ID

6374290

DOI

10.1016/0022-4804(84)90138-0

Scopus ID

2-s2.0-0021238069   11 Citations

Abstract

Donor-specific transfusions ( DSTs ) using stored and fresh blood were investigated in a rat heart allograft model. Lewis rats were recipients of preoperative DSTs and cardiac allografts from ACI donors. Blood was stored for 0, 1, 2, 3, 4, and 5 weeks prior to transfusion. Allograft survival and recipient sensitization were recorded. In all DST groups, allograft survival was superior to nontransfused controls (P less than 0.05). Stored blood was equal or better than fresh blood, and a 2-week storage was optimal (P less than 0.05). Storage of 2 weeks or greater resulted in decreased sensitization compared to storage for 1 week or less (P less than 0.05). This study supports the use of stored blood to enhance allograft survival and reduce recipient sensitization.

Author List

Johnson CP, Munda R, Balakrishnan K, Alexander JW

Author

Christopher P. Johnson MD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Donors
Blood Grouping and Crossmatching
Blood Preservation
Blood Transfusion
Graft Survival
Heart Transplantation
Humans
Male
Rats
Rats, Inbred ACI
Rats, Inbred Lew
Time Factors
Tissue Donors
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00