Faculty Collaboration Database

A device for noninvasive assessment of vascular impairment risk in the lower extremity. IEEE Trans Biomed Eng 2008 Dec;55(12):2786-91

Date

01/08/2009

Pubmed ID

19126459

DOI

10.1109/TBME.2008.925695

Scopus ID

2-s2.0-58149252212 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

The repeatability and resolution of the clinical gold standard of vascular assessment, the ankle-brachial index (ABI), was compared to that of a new device that dynamically assesses tissue perfusion during external loading utilizing laser Doppler flowmetry. Eight subjects of varying levels of vascular impairment were tested in successive weeks using two different sites on the subject's posterior calf. These new measures included the perfusion decrease as well as the unloading delay during cyclic loading. Some new dynamic tissue perfusion measures demonstrated comparable levels of reproducibility with the ABI (e.g., 10%-20%). Only the unloading delay showed potentially enhanced resolution over ABI measures. The perfusion decrease showed little resolution, and the remaining parameters exhibited too great variability (25%-90%). The unloading delay associated with the reperfusion response during cyclic loading displayed the greatest combination of reproducibility and differentiation between subject groups of varying levels of vascular impairment. The preliminary results of this pilot study were also used to estimate sample sizes necessary to detect possible significant (P<0.05) differences between subject groups for all measured perfusion parameters. From these calculations, at least 30 subjects are needed for future study in each of the five subject groups.

Author List

Hoffmann MJ, Knudson PE, Silver-Thorn MB

Author

Paul Knudson MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Amputees
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Early Diagnosis
Hemorheology
Humans
Ischemia
Laser-Doppler Flowmetry
Leg
Middle Aged
Peripheral Vascular Diseases
Plethysmography
Pressure
Regional Blood Flow
Reperfusion
Risk Assessment