Semantic knowledge for famous names in mild cognitive impairment. J Int Neuropsychol Soc 2009 Jan;15(1):9-18
Date
01/09/2009Pubmed ID
19128524Pubmed Central ID
PMC2774216DOI
10.1017/S1355617708090103Scopus ID
2-s2.0-61949170018 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Person identification represents a unique category of semantic knowledge that is commonly impaired in Alzheimer's disease (AD), but has received relatively little investigation in patients with mild cognitive impairment (MCI). The current study examined the retrieval of semantic knowledge for famous names from three time epochs (recent, remote, and enduring) in two participant groups: 23 amnestic MCI (aMCI) patients and 23 healthy elderly controls. The aMCI group was less accurate and produced less semantic knowledge than controls for famous names. Names from the enduring period were recognized faster than both recent and remote names in both groups, and remote names were recognized more quickly than recent names. Episodic memory performance was correlated with greater semantic knowledge particularly for recent names. We suggest that the anterograde memory deficits in the aMCI group interferes with learning of recent famous names and as a result produces difficulties with updating and integrating new semantic information with previously stored information. The implications of these findings for characterizing semantic memory deficits in MCI are discussed. (JINS, 2009, 15, 9-18.).
Author List
Seidenberg M, Guidotti L, Nielson KA, Woodard JL, Durgerian S, Zhang Q, Gander A, Antuono P, Rao SMAuthors
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinKristy Nielson PhD Professor in the Psychology department at Marquette University
MESH terms used to index this publication - Major topics in bold
AgedArousal
Cognition Disorders
Data Interpretation, Statistical
Emotions
Famous Persons
Female
Humans
Knowledge
Magnetic Resonance Imaging
Male
Memory
Psychomotor Performance
