Faculty Collaboration Database

Codon 129 polymorphism of prion protein gene in sporadic Alzheimer's disease. Eur J Neurol 2008 Feb;15(2):173-8

Date

01/26/2008

Pubmed ID

18217885

DOI

10.1111/j.1468-1331.2007.02021.x

Scopus ID

2-s2.0-38349132020 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Codon 129 polymorphism of the prion protein gene represents a major genetic risk factor for Creutzfeldt-Jakob disease (CJD). Both CJD and Alzheimer's disease (AD) are brain amyloidoses and it would be possible that codon 129 polymorphism plays a role in the susceptibility to AD. In order to investigate this polymorphism in AD the distribution of polymorphic codon 129 of the PRNP gene in 194 probable AD and 124 controls selected in Italy and 109 neuropathologically verified AD and 58 matched controls recruited in the USA was studied. No significant association was found for the PRNP polymorphism in AD compared to controls either in Probable or in Definite AD series even after stratification for APOE polymorphism. This study does not support a role of PRNP polymorphism as a susceptibility factor for AD.

Author List

Poleggi A, Bizzarro A, Acciarri A, Antuono P, Bagnoli S, Cellini E, Forno GD, Giannattasio C, Lauria A, Matera MG, Nacmias B, Puopolo M, Seripa D, Sorbi S, Wekstein DR, Pocchiari M, Masullo C

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Alzheimer Disease
Apolipoproteins E
Codon
Female
Genetic Predisposition to Disease
Humans
Italy
Male
Middle Aged
Polymorphism, Genetic
Prion Proteins
Prions
United States