Faculty Collaboration Database

Psychopharmacological prospectives in the treatment of dementia. Prog Neuropsychopharmacol 1979;3(1-3):75-80

Date

01/01/1979

Pubmed ID

401345

DOI

10.1016/0364-7722(79)90072-9

Scopus ID

2-s2.0-0018604454 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

1. Dementias have a complex etiology and pathogenesis which should be carefully evaluated in order to attempt a medical treatment. 2. Drugs are among the most frequent causes of dementias, particularly drugs with anticholinergic properties. 3. A similarity between the mental symptoms of anticholinergic poisoning and senile dementia has been observed. 4. Recent investigations have also presented a decrease of cholinergic activity in postmortem material of subjects with Alzheimer's disease. Also a number of data suggest that recent memory would be related to changes in the metabolism of brain acetylcholine (Ach). 5. The possibility that drugs stimulating brain cholinergic mechanisms might be used in the treatment of dementias is envisaged.

Author List

Antuono P, Amaducci L, Pazzagli A, Pepeu G

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Central Nervous System
Dementia
Humans
Parasympathomimetics
Psychopharmacology
Sympathetic Nervous System
Sympatholytics