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A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain. Neurochem Res 1978 Dec;3(6):725-31

Date

12/01/1978

Pubmed ID

740126

DOI

10.1007/BF00965995

Scopus ID

2-s2.0-0018255677 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Lecithin:cholesterol acyltransferase (LCAT) activity has been examined in the rat by using a brain homogenate preparation as the phospholipid substrate and blood plasma as the enzyme source. LCAT activity was detected on using 60 mul of serum onwards. Successive experiments have also shown that LCAT activity is present in the edematous rat brain tissue homogenate when incubated with inactivated rat plasma as substrate. The results are discussed in relation to cholesteryl ester accumulation in brain during demyelinating diseases.

Author List

Amaducci L, Antuono P, Bartolini L, De Medio GE, Inzitari D, Porcellati G

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Brain
Brain Edema
Cholesterol Esters
Demyelinating Diseases
Male
Phosphatidylcholine-Sterol O-Acyltransferase
Phospholipids
Rats