A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain. Neurochem Res 1978 Dec;3(6):725-31
Date
12/01/1978Pubmed ID
740126DOI
10.1007/BF00965995Scopus ID
2-s2.0-0018255677 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Lecithin:cholesterol acyltransferase (LCAT) activity has been examined in the rat by using a brain homogenate preparation as the phospholipid substrate and blood plasma as the enzyme source. LCAT activity was detected on using 60 mul of serum onwards. Successive experiments have also shown that LCAT activity is present in the edematous rat brain tissue homogenate when incubated with inactivated rat plasma as substrate. The results are discussed in relation to cholesteryl ester accumulation in brain during demyelinating diseases.
Author List
Amaducci L, Antuono P, Bartolini L, De Medio GE, Inzitari D, Porcellati GAuthor
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Brain Edema
Cholesterol Esters
Demyelinating Diseases
Male
Phosphatidylcholine-Sterol O-Acyltransferase
Phospholipids
Rats