Faculty Collaboration Database

Crystalline arthropathy and bone health. Curr Opin Rheumatol 2018 Mar;30(2):173-176

Date

12/02/2017

Pubmed ID

29194109

DOI

10.1097/BOR.0000000000000469

Scopus ID

2-s2.0-85042408789 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

PURPOSE OF REVIEW: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance.

RECENT FINDINGS: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. A recent systematic review and meta-analysis of available literature showed a correlation between increased serum uric acid and lower risk of fracture. Less is known about calcium pyrophosphate deposition disease and bone health, although two large studies have suggested an association with osteopenia.

SUMMARY: A systematic review and meta-analysis of available data suggest a correlation between increased serum uric acid and lower risk of fracture. Findings support an association between bone health and crystal arthritis which warrants further study and may have implications for how we treat gout.

Author List

Chang I, Gazeley D

Author

David J. Gazeley MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Bone Density
Bone and Bones
Chondrocalcinosis
Crystal Arthropathies
Fractures, Bone
Gout
Humans
Hyperuricemia
Uric Acid