Crystalline arthropathy and bone health. Curr Opin Rheumatol 2018 Mar;30(2):173-176
Date
12/02/2017Pubmed ID
29194109DOI
10.1097/BOR.0000000000000469Scopus ID
2-s2.0-85042408789 (requires institutional sign-in at Scopus site) 1 CitationAbstract
PURPOSE OF REVIEW: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance.
RECENT FINDINGS: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. A recent systematic review and meta-analysis of available literature showed a correlation between increased serum uric acid and lower risk of fracture. Less is known about calcium pyrophosphate deposition disease and bone health, although two large studies have suggested an association with osteopenia.
SUMMARY: A systematic review and meta-analysis of available data suggest a correlation between increased serum uric acid and lower risk of fracture. Findings support an association between bone health and crystal arthritis which warrants further study and may have implications for how we treat gout.
Author List
Chang I, Gazeley DAuthor
David J. Gazeley MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bone DensityBone and Bones
Chondrocalcinosis
Crystal Arthropathies
Fractures, Bone
Gout
Humans
Hyperuricemia
Uric Acid