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The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochem Biophys Res Commun 1985 Sep 16;131(2):731-5

Date

09/16/1985

Pubmed ID

4052072

DOI

10.1016/0006-291x(85)91299-9

Scopus ID

2-s2.0-0022350089 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

The clonal proliferation of chicken granulocytic progenitors was inhibited 5-20-fold by the eicosanoid, 5-HETE, at 1.0 microM. Inhibition occurred at the lowest concentration measured (0.12 microM). This compound at 0.6 to 1.0 microM also inhibited the clonal proliferation of chick embryo fibroblasts by as much as 10-fold.

Author List

Dodge W, Thomas M

Author

Michael J. Thomas PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Bone Marrow Cells
Cell Division
Cells, Cultured
Chick Embryo
Chickens
Fibroblasts
Granulocytes
Hematopoietic Stem Cells
Hydroxyeicosatetraenoic Acids