Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma. Ann Oncol 2012 Mar;23(3):736-742
Date
05/24/2011Pubmed ID
21602260Pubmed Central ID
PMC3331732DOI
10.1093/annonc/mdr157Scopus ID
2-s2.0-84857534118 (requires institutional sign-in at Scopus site) 85 CitationsAbstract
BACKGROUND: A recent study demonstrated that an increased number of CD68+ macrophages were correlated with primary treatment failure, shortened progression-free survival (PFS) and disease-specific survival (DSS) in patients with classical Hodgkin's lymphoma (cHL).
PATIENTS AND METHODS: The aim of the present study was to verify the relationship between the number of CD68+ and CD163+ macrophages with clinical outcomes in a cohort of 265 well-characterized patients with cHL treated uniformly with the standard doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy regimen. Two pairs of hematopathologists carried out independent pathological evaluations of tissue microarray slides.
RESULTS: There were no associations between clinical characteristics and the expression of CD68 or CD163. However, higher levels of CD68 and CD163 expression were correlated with the presence of Epstein-Barr virus-positive Hodgkin tumor cells (P = 0.01 and 0.037, respectively). The expression of CD68 or CD163 was not associated with either the PFS or the DSS.
CONCLUSION: CD68 and CD163 expression require further evaluation before their use can be recommended for prognostic stratification of patients with cHL.
Author List
Azambuja D, Natkunam Y, Biasoli I, Lossos IS, Anderson MW, Morais JC, Spector NAuthor
Matthew W. Anderson MD, PhD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Antineoplastic Combined Chemotherapy Protocols
Disease-Free Survival
Epstein-Barr Virus Infections
Female
Hodgkin Disease
Humans
Immunohistochemistry
In Situ Hybridization
Kaplan-Meier Estimate
Macrophages
Male
Middle Aged
Prognosis
Receptors, Cell Surface
Tissue Array Analysis
Treatment Outcome
Young Adult
