Invasive aspergillosis of paranasal tissues in children with malignancies. J Pediatr 1983 Jul;103(1):49-53
Date
07/01/1983Pubmed ID
6575168DOI
10.1016/s0022-3476(83)80774-4Scopus ID
2-s2.0-0020505378 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Paranasal aspergillosis was encountered in five children with relapsed malignancies. All had received broad-spectrum antibiotics within two weeks of development of aspergillosis, and all had absolute granulocyte counts less than 200/mm3 for at least three weeks. None had received prior antifungal therapy. There was an average delay of eight days before the correct diagnosis was established by either biopsy or culture. These data emphasize the need to obtain surveillance cultures of the upper respiratory tract passages in severely neutropenic patients receiving prolonged antibiotic therapy, and raise a question concerning prophylactic use of antifungal therapy in this group.
Author List
Berkow RL, Weisman SJ, Provisor AJ, Weetman RM, Baehner RLAuthor
Steven J. Weisman MD Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAnti-Bacterial Agents
Aspergillosis
Child
Child, Preschool
Humans
Leukemia, Lymphoid
Male
Neutropenia
Paranasal Sinus Diseases
Time Factors
