Validation of left ventricular end-diastolic volume from stroke volume and ejection fraction. ASAIO J 2002;48(6):654-7
Date
11/29/2002Pubmed ID
12455778DOI
10.1097/00002480-200211000-00014Scopus ID
2-s2.0-1842837165 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
The present study examines an innovative approach to measurement of left ventricular (LV) end-diastolic volume (LVEDV). Measurement of LVEDV is fundamental to the assessment of intraoperative systolic and diastolic LV function. We compared steady state LVEDV values obtained from stroke volume (SV) and ejection fraction (EF) with echocardiographic and postmortem LVEDV measurements. Five anesthetized pigs (40-45 kg) underwent median sternotomy and pericardiotomy. A transit time ultrasonic flow probe was placed on the ascending aorta to provide cardiac output. A micromanometer provided LV end-diastolic pressure. LV short axis cross sectional echocardiograms and electrocardiograms were also obtained. LV end-diastolic area (LVEDA) and end-systolic area (LVESA) were measured to obtain EF. LVEDVsv/ef was calculated from cardiac output, heart rate, and EF. LVEDVecho was determined using a three-plane echocardiography model. Postmortem (LVEDVpm/vv) volumes were also measured. LVEDVsv/ef correlated well with volumes obtained by echocardiography (r2 = 0.92) and postmortem (r2 = 0.73) measurements. Values of p < 0.05 indicated significant linearity of LVEDA-LVEDVsv/ef (r2 =0.93), LVEDA-LVEDVecho (r2 = 0.96), and LVEDA-LVEDVpm/vv (r2 = 0.81) relationships. Determination of LVEDV from SV and EF is valid and may facilitate real-time determination of LV mechanics.
Author List
Hart JP, Cabreriza SE, Gallup CG, Hsu D, Spotnitzt HMAuthor
Joseph Hart MD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDiastole
Echocardiography, Three-Dimensional
Heart Diseases
Heart Rate
Linear Models
Stroke Volume
Swine
Systole
Ventricular Function, Left
