Faculty Collaboration Database

Longitudinal thumbnail fissures due to erlotinib therapy for lung cancer. J Oncol Pharm Pract 2018 Apr;24(3):229-231

Date

04/25/2017

Pubmed ID

28436313

DOI

10.1177/1078155217698845

Scopus ID

2-s2.0-85044117008 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

While therapy with epidermal growth factor receptor inhibitors leads to meaningful clinical responses in several tumor types, it has also been linked with perplexing toxic effects. Skin effects of these agents such as generalized papulo-pustular rash, trichomegaly, fingertip fissures, xerosis, pruritus and paronichias are now well characterized. Though uncommon, nail atrophic changes have also been described in subjects treated with these classes of agents. We describe herein unusual longitudinal thumbnail fissures caused by erlotinib therapy for metastatic lung cancer. Unique features are bilateral thumbnail involvement and central location in the nail bed. This side effect of erlotinib has not been previously reported in the medical literature.

Author List

Dasanu CA, Alvarez-Argote J, Lippman SM, Plaxe SC

Author

Juliana Alvarez Argote MD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Antineoplastic Agents
Drug Eruptions
Erlotinib Hydrochloride
Humans
Lung Neoplasms
Male
Middle Aged
Nail Diseases
Protein Kinase Inhibitors
Thumb