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Emergence of multidrug-resistant Salmonella enterica serotype Newport infections resistant to expanded-spectrum cephalosporins in the United States. J Infect Dis 2003 Dec 01;188(11):1707-16

Date

11/26/2003

Pubmed ID

14639542

DOI

10.1086/379668

Scopus ID

2-s2.0-0346256761 (requires institutional sign-in at Scopus site)   207 Citations

Abstract

We describe a field investigation in New England that identified the emergence and epidemiology of new strains of multidrug-resistant Salmonella, Newport-MDRAmpC, and summarize the Center for Disease Control and Prevention's surveillance data for these infections. In Massachusetts, the prevalence of Newport-MDRAmpC among Salmonella serotype Newport isolates obtained from humans increased from 0% (0/14) in 1998 to 53% (32/60) in 2001 (P<.001). In a retrospective case-control study, infection with Newport-MDRAmpC was domestically acquired and was associated with exposure to a dairy farm. Isolates from both humans and cattle had indistinguishable or closely related antibiograms and pulsed-field gel electrophoresis patterns. Nationally, the prevalence of ceftriaxone-resistant Salmonella increased from 0.5% in 1998 to 2.4% in 2001; 85% of the isolates in 2001 were Newport-MDRAmpC, and at least 27 states have isolated these strains from humans, cattle, or ground beef. These data document the widespread emergence of Newport-MDRAmpC strains in the United States and show that the 5-fold increase in the prevalence of Salmonella resistant to expanded-spectrum cephalosporins, between 1998 and 2001, is primarily due to the emergence of Newport-MDRAmpC strains.

Author List

Gupta A, Fontana J, Crowe C, Bolstorff B, Stout A, Van Duyne S, Hoekstra MP, Whichard JM, Barrett TJ, Angulo FJ, National Antimicrobial Resistance Monitoring System PulseNet Working Group

Author

Colleen Crowe MD Associate Professor in the Emergency Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Aged, 80 and over
Animals
Bacterial Proteins
Case-Control Studies
Cattle
Cephalosporin Resistance
Child
Child, Preschool
Drug Resistance, Multiple, Bacterial
Female
Food Microbiology
Humans
Infant
Male
Middle Aged
Salmonella Infections
Salmonella enterica
Serotyping
beta-Lactamases