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Diffuse Midline Glioma With Osseous Metastases at Diagnosis: A Case Report. J Pediatr Hematol Oncol 2020 10;42(7):e673-e676

Date

10/01/2019

Pubmed ID

31568066

DOI

10.1097/MPH.0000000000001598

Scopus ID

2-s2.0-85091808908   4 Citations

Abstract

Extraneural metastasis is extremely rare in pediatric patients with high-grade glioma and carries a grim prognosis. Detection of metastases at initial presentation is even rarer. A 15-year-old adolescent girl presented with paraplegia, urinary retention, and a constellation of systemic symptoms. Imaging showed a fourth ventricular lesion, innumerable intradural lesions, leptomeningeal seeding throughout the neuraxis, and numerous osteoblastic lesions involving the spine, ribs, sternum, pelvis, humerus, and femurs. Pathology confirmed metastatic diffuse midline glioma, H3K27M-mutant. Our patient died 2 weeks after initial presentation. Further work is needed to develop effective treatment strategies for these high-risk patients.

Author List

Bhatt NS, Houser K, Belongia M, Ellison DW, Foy A, Jarzembowski J, Kelly T, Maheshwari M, Suchi M, Knipstein J

Authors

Andrew Foy MD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Jason A. Jarzembowski MD, PhD Sr Associate Dean, CEO CSG, Professor in the Pathology department at Medical College of Wisconsin
Mohit Maheshwari MD Professor in the Radiology department at Medical College of Wisconsin
Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Bone Neoplasms
Brain Neoplasms
Fatal Outcome
Female
Glioma
Histones
Humans
Mutation