Impact of Donor Milk on Short- and Long-Term Growth of Very Low Birth Weight Infants. Nutrients 2019 Jan 22;11(2)
Date
01/27/2019Pubmed ID
30678256Pubmed Central ID
PMC6412258DOI
10.3390/nu11020241Scopus ID
2-s2.0-85060510319 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Mother's own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20⁻24 months corrected age in VLBW infants who received MOM supplements of preterm formula (n = 160) versus fortified DM (n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27.3 weeks. Multilevel linear growth models assessed changes in growth z-scores short-term (to NICU discharge) and long-term (post-discharge), controlling for amount of DM or formula received in first 28 days of life, NICU length of stay (LOS), birth GA, and sex. Z-scores for weight and length decreased during hospitalization but increased for all parameters including head circumference post-discharge. Short-term growth was positively associated with LOS and birth GA. A higher preterm formula proportion, but not DM proportion, was associated with slower rates of decline in short-term growth trajectories, but feeding type was unrelated to long-term growth. In conclusion, controlling for total human milk fed, DM did not affect short- or long-term growth.
Author List
Hoban R, Schoeny ME, Esquerra-Zwiers A, Kaenkumchorn TK, Casini G, Tobin G, Siegel AH, Patra K, Hamilton M, Wicks J, Meier P, Patel ALAuthor
Tanyaporn Kaenkumchorn MD Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Breast FeedingChild Development
Cohort Studies
Female
Humans
Infant Formula
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care, Neonatal
Male
Milk Banks
Milk, Human
Retrospective Studies