Faculty Collaboration Database

Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol 2015 Apr;72(4):606-16.e4

Date

03/17/2015

Pubmed ID

25773409

DOI

10.1016/j.jaad.2014.12.013

Scopus ID

2-s2.0-84929514810 (requires institutional sign-in at Scopus site)   213 Citations

Abstract

BACKGROUND: Previous studies found conflicting results about whether atopic dermatitis (AD) is associated with overweight/obesity.

OBJECTIVE: We sought to examine the relationship between AD and overweight/obesity by performing a systematic review and metaanalysis.

METHODS: Observational studies of the relationship between AD and overweight/obesity were selected from PubMed, Embase, and the Cochrane Library. The quality of evidence was assessed using the Newcastle-Ottawa Scale. Fixed and random effects metaanalyses were performed to estimate pooled odds ratios (ORs). Sensitivity analyses were performed that compared results by location of study, study quality, and between studies in children and adults.

RESULTS: In total, 30 studies were included for review. Patients who were overweight (Cochrane-Mantel-Haenszel [CMH] OR, 1.27 [95% confidence interval {CI}: 1.19-1.36]; random effects OR, 1.23 [95% CI: 1.11-1.41]), obese (CMH OR, 1.68 [95% CI: 1.54-1.84]; random effects OR, 1.47 [95% CI: 1.21-1.79]), or overweight/obese (CMH OR, 1.42 [95% CI: 1.34-1.50]; random effects OR, 1.31 [95% CI: 1.16-1.48]) had higher odds of AD than normal weight patients. In sensitivity analyses, children who were overweight (random effects OR, 1.24 [95% CI: 1.08-1.43]), obese (random effects OR, 1.44 [95% CI: 1.12-1.86]), or overweight/obese (random effects OR, 1.32 [95% CI: 1.15-1.51]) and adults who were obese (random effects OR, 1.56 [95% CI: 1.24-1.95]) or overweight/obese (random effects OR, 1.29 [95% CI: 1.05-1.59]) had higher odds of AD. The association remained significant in North America and Asia but not Europe.

LIMITATIONS: Most studies were cross-sectional.

CONCLUSIONS: Overweight/obesity in North America and Asia is associated with an increased prevalence of AD.

Author List

Zhang A, Silverberg JI

Authors

Keely Morris Marshall MD, PhD Assistant Professor in the Dermatology department at Medical College of Wisconsin
April Zhang MD Staff Physician in the Dermatology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Body Mass Index
Child
Cohort Studies
Cross-Sectional Studies
Dermatitis, Atopic
Eczema
Female
Global Health
Humans
Male
Obesity
Observational Studies as Topic
Odds Ratio
Overweight
Publication Bias