Clinicopathologic Features of Small Renal Masses Associated With Distant Metastatic Disease. Am J Clin Pathol 2020 Apr 15;153(5):613-617
Date
12/19/2019Pubmed ID
31848569DOI
10.1093/ajcp/aqz202Scopus ID
2-s2.0-85083882337 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
OBJECTIVES: To assess the clinicopathologic features of small renal masses (≤4 cm) associated with distant metastatic disease.
METHODS: We identified radical or partial nephrectomies with renal cell carcinomas (RCCs) measuring 4 cm or less in size (pT1a or pT3a) from 2005 to 2015. Clinicopathologic features were compiled.
RESULTS: A total of 590 RCCs 4 cm or less were identified, of which 3.9% were associated with distant metastatic RCC. Metastasis was more common in pT3a tumors 4 cm or less than pT1a tumors (19% vs 2.7%; P < .01). Seventy percent of tumors were clear cell RCCs. Overall, 43% of patients had previously (30%) or subsequently (13%) diagnosed RCC prior to development of metastasis, 80% of which were the same histologic subtype as the small renal mass.
CONCLUSIONS: Distant metastatic disease was rarely encountered in patients with small renal masses. Many of the patients with distant metastases had previously or subsequently diagnosed RCC, which could represent the true source of metastatic disease.
Author List
Gallan AJ, Antic TAuthor
Alexander J. Gallan MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedCarcinoma, Renal Cell
Female
Humans
Kidney
Kidney Neoplasms
Male
Middle Aged
Nephrectomy
