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Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats. Prostaglandins Leukot Med 1982 Feb;8(2):93-103

Date

02/01/1982

Pubmed ID

6804992

DOI

10.1016/s0262-1746(82)80001-2

Abstract

Thrombin induced thromboxane A2 and prostaglandin E2 production were significantly increased in platelets of streptozotocin induced diabetic rats as compared to non-diabetic control rats, while collagen induced thromboxane A2 production was decreased. Using exogenous arachidonic acid, prostaglandin E2 production, but not thromboxane A2 production, was increased in platelets from streptozotocin treated animals. Prostacyclin production in the diabetic aorta was significantly lowered; however, control levels of prostacyclin production resulted after incubation of the tissue with dipyridamole. Diabetic animals demonstrated a fivefold decrease in the endogenous arterial prostacyclin/platelet thromboxane A2 ration when thrombin or ADP was used to induce thromboxane A2 production. This elevated ratio could be a contributing factor to the vascular complications of diabetes. Dipyridamole, due to its ability to partially normalize this ratio, may be useful as a therapeutic agent in this and related vascular diseases.

Author List

Karpen CW, Pritchard KA Jr, Merola AJ, Panganamala RV

Author

Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Aorta, Thoracic
Arachidonic Acid
Arachidonic Acids
Blood Platelets
Diabetes Mellitus, Experimental
Dinoprostone
Dipyridamole
Epoprostenol
Male
Prostaglandins
Prostaglandins E
Rats
Rats, Inbred Strains
Thrombin
Thromboxane A2
Thromboxanes
Time Factors
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a