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Fever in a transplant recipient: think beyond infection. Clin Case Rep 2018 04;6(4):651-652

Date

04/11/2018

Pubmed ID

29636933

Pubmed Central ID

PMC5889273

DOI

10.1002/ccr3.1432

Abstract

Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated inflammatory cascade initiated in response to immune recovery during the resolution of an infection. Reduction in calcineurin inhibitor levels in organ transplant recipients due to enhanced metabolism from interaction with rifampin can predispose these individuals to develop IRIS during the treatment of tuberculosis and mimic sepsis.

Author List

Kamboj M, Chornyy V, Koratala A, Santos AH

Author

Abhilash Koratala MD Associate Professor in the Medicine department at Medical College of Wisconsin