Fever in a transplant recipient: think beyond infection. Clin Case Rep 2018 Apr;6(4):651-652
Date
04/11/2018Pubmed ID
29636933Pubmed Central ID
PMC5889273DOI
10.1002/ccr3.1432Abstract
Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated inflammatory cascade initiated in response to immune recovery during the resolution of an infection. Reduction in calcineurin inhibitor levels in organ transplant recipients due to enhanced metabolism from interaction with rifampin can predispose these individuals to develop IRIS during the treatment of tuberculosis and mimic sepsis.