Faculty Collaboration Database

Relations Between Physical Activity, Subclinical Myocardial Injury, and Cardiovascular Mortality in the General Population. Am J Cardiol 2020 Jan 15;125(2):205-209

Date

12/19/2019

Pubmed ID

31847957

DOI

10.1016/j.amjcard.2019.08.031

Scopus ID

2-s2.0-85076792051 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

We examined the association between poor physical activity (PA) and subclinical myocardial injury (SC-MI), and how concomitant exposure to poor PA and SC-MI modifies their association with cardiovascular disease (CVD) mortality. This analysis included 6,044 participants free of CVD from the NHANES-III survey. Leisure time PA was defined as: ideal (3 to 5.99 METs and ≥5 times/week or any PA with ≥6METs and ≥3times/week), intermediate (any activity other than ideal), or poor (no activity at all). SC-MI was defined as an electrocardiographic cardiac infarction/injury score ≥10 units. CVD mortality was ascertained from the National Death Index. In multivariable logistic regression analysis, poor PA (odds ratio [OR] [95% confidence interval, CI]: 1.30 [1.10 to 1.54]) and intermediate PA (OR [95%CI]: 1.19 [1.02 to 1.38]), compared with ideal PA, were associated with an increased odds of SC-MI. During a median follow-up of 14 years, 589 CVD deaths occurred. In multivariable Cox-proportional hazard analysis, the presence (vs absence) of SC-MI was associated with a 33% increased risk of CVD mortality whereas poor (vs ideal) PA was associated with a 67% increased risk of CVD mortality (HR [95%CI]: 1.33 [1.11 to 1.58] and 1.67 [1.37 to 2.05], respectively). Additionally, the concomitant presence of both poor PA and SC-MI were associated with a higher risk of CVD mortality (HR [95%CI]: 2.25[1.68 to 3.00]) compared with ideal PA and the absence of SC-MI. In conclusion, poor PA is associated with an increased risk of SC-MI and their concomitant presence is associated with a marked increase in CVD mortality, underscoring the potential role of PA in preventing clinical and subclinical CVD outcomes.

Author List

German C, Ahmad MI, Li Y, Soliman EZ

Author

Muhammad Imtiaz Ahmad MBBS Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cardiovascular Diseases
Cause of Death
Electrocardiography
Exercise
Exercise Test
Female
Humans
Male
Middle Aged
Myocardial Infarction
Nutrition Surveys
Risk Factors
Survival Rate
United States