Faculty Collaboration Database

Visual Acuity and Foveal Structure in Eyes with Fragmented Foveal Avascular Zones. Ophthalmol Retina 2020 May;4(5):535-544

Date

01/21/2020

Pubmed ID

31956075

Pubmed Central ID

PMC7211138

DOI

10.1016/j.oret.2019.11.014

Scopus ID

2-s2.0-85078051790 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

PURPOSE: To assess the frequency and impact of abnormal foveal avascular zone (FAZ) topography (i.e., a fragmented FAZ) on visual acuity and foveal anatomic features.

DESIGN: Prospective, cross-sectional study from March 2018 through July 2019.

PARTICIPANTS: Two-hundred fifty participants were screened from a normative OCT angiography database. Of those, 12 participants were found to have at least 1 eye with a fragmented FAZ. Eight returned for follow-up imaging, along with an additional 3 participants with ocular disease (amblyopia, autosomal recessive bestrophinopathy, premature birth) having a similar FAZ phenotype.

METHODS: Follow-up OCT imaging and monocular best-corrected visual acuity (BCVA) were performed for these 11 participants. Twenty-four participants with a clearly defined FAZ were recruited for comparison. A normative database was created measuring parafoveal intercapillary area (PICA) to determine if an FAZ was fragmented.

MAIN OUTCOME MEASURES: Monocular BCVA, foveal pit depth, foveal pit area, PICA, outer nuclear layer thickness, foveal inner retinal area, and peak cone density.

RESULTS: The frequency of a fragmented FAZ was 4.8% of individuals (12 of 250) or 3.6% of eyes (18 of 500 eyes). A significant difference was found between the control eyes and eyes with fragmented FAZs for foveal pit depth, pit area, and total PICA (P < 0.001, P = 0.002, and P < 0.001, respectively). The presence of a fragmented FAZ did not affect visual acuity.

CONCLUSIONS: The presence of a fragmented FAZ seems not to be a rare phenotype in individuals with normal vision. The presence of altered FAZ topography in patients with retinal or systemic disease could negatively impact the accuracy and sensitivity of biomarkers dependent on FAZ identification.

Author List

Linderman RE, Cava JA, Salmon AE, Chui TY, Marmorstein AD, Lujan BJ, Rosen RB, Carroll J

Author

Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Child
Cross-Sectional Studies
Female
Fluorescein Angiography
Fovea Centralis
Fundus Oculi
Humans
Male
Prospective Studies
Retinal Vessels
Tomography, Optical Coherence
Visual Acuity
Young Adult