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Vitamin E attenuates the effects of FMLP on rabbit circulating granulocytes. Pediatr Res 1984 Jun;18(6):536-40

Date

06/01/1984

Pubmed ID

6739193

DOI

10.1203/00006450-198406000-00011

Abstract

Exposure of circulating rabbit granulocytes to the chemoattractant N-formyl-methionyl-leucyl-phenylalanine (FMLP) in vivo results in transient granulocytopenia, hypotension, and cardiorespiratory distress. The effectiveness of vitamin E in attenuating these responses was tested. Vitamin E accelerated the rate of return of granulocytes to the peripheral circulation after FMLP-induced granulocytopenia and mitigated the hypotension. The reversible adherence of FMLP-stimulated granulocytes to endothelium offers a plausible mechanism to explain the transient granulocytopenia. From in vitro studies it was found that FMLP-activated granulocytes from animals treated with vitamin E showed decreased adherence to cultivated aortic endothelial monolayers when compared with FMLP-activated granulocytes from control animals.

Author List

Lafuze JE, Weisman SJ, Alpert LA, Baehner RL

Author

Steven J. Weisman MD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Agranulocytosis
Animals
Blood Pressure
Cell Adhesion
Granulocytes
Heart Rate
Hypotension
Lymphocyte Activation
Male
N-Formylmethionine Leucyl-Phenylalanine
Rabbits
Respiration
Respiratory Insufficiency
Vitamin E
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d