Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms. Neuroimage Clin 2020;26:102217
Date
02/29/2020Pubmed ID
32109760Pubmed Central ID
PMC7044530DOI
10.1016/j.nicl.2020.102217Scopus ID
2-s2.0-85079900353 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Approximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hypothesis that amygdalae reactivity to emotional faces in adolescents with PPCS+ is elevated compared to concussed adolescents without PPCS and healthy controls. Concussed adolescents (ages 14-18) with (PPCS+; n = 23) and without PPCS (PPCS-; n = 13) participated in visits at least 4 weeks post-injury. Adolescents without prior concussion served as controls (HC; n = 15). All participants completed a detailed clinical battery and a common emotional face processing task that involved matching of emotional faces or shapes. Compared to HC and PPCS-, adolescents with PPCS+ had elevated depression symptoms, anhedonia, general psychological symptoms, and anxiety symptoms. Contrary to our hypothesis, PPCS+ had lower amygdalae activity to the emotional faces versus shapes condition relative to HC and a trend for lower activity relative to PPCS-. There was a non-significant inverse association between anhedonia amygdalae activity in adolescents with PPCS. Results suggest that adolescents with PPCS have altered amygdalae activity during the processing of emotional face stimuli.
Author List
Bohorquez-Montoya L, España LY, Nader AM, Furger RE, Mayer AR, Meier TBAuthor
Timothy B. Meier PhD Associate Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAmygdala
Emotions
Facial Recognition
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Male
Post-Concussion Syndrome
