Faculty Collaboration Database

The effects of chronic administration of naltrexone on appetite and water exchange in rats. Pharmacol Biochem Behav 1982 Jun;16(6):909-13

Date

06/01/1982

Pubmed ID

7111349

DOI

10.1016/0091-3057(82)90043-0

Scopus ID

2-s2.0-0019983569 (requires institutional sign-in at Scopus site)   29 Citations

Abstract

The effects of chronic administration of naltrexone (200 microgram/kg/hr) on appetitive behaviors and renal water and electrolyte excretions were studied in rats. Naltrexone reduced food and water intake, the renal excretions of water and electrolyte excretions were studied in rats. Naltrexone reduced food and water intake, the renal excretions of water and electrolytes, and osmolar clearance. No changes in plasma levels of electrolytes, plasma and urine Na+-K+ ratios, hematocrit ratio, plasma osmolality, the clearances of K+ and Na+, and the reabsorption of solute free water were found. The changes in appetite were compensated for by appropriate changes in renal excretions, resulting in no change in electrolyte balance or water exchange. These observations are discussed in relation to current theories of the role of endorphins in appetite control.

Author List

Lang IM, Strahlendorf JC, Strahlendorf HK, Lutherer LO, Barnes CD

Author

Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Appetite
Drinking
Eating
Kidney Concentrating Ability
Male
Naloxone
Naltrexone
Rats
Rats, Inbred Strains
Water-Electrolyte Balance