Faculty Collaboration Database

Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty. J Orthop Res 2020 Jul;38(7):1506-1514

Date

03/13/2020

Pubmed ID

32162716

Pubmed Central ID

PMC8100875

DOI

10.1002/jor.24654

Scopus ID

2-s2.0-85082142657 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

The failure of total hip arthroplasty (THA) is commonly associated with the necrosis of the periprosthetic tissue. To date, there is no established method to noninvasively quantify the progression of such necrosis. Magnetic resonance imaging (MRI) of soft tissues near implants has undergone a recent renaissance due to the development of multispectral metal-artifact reduction techniques. Advanced analysis of multispectral MRI has been shown capable of detecting small magnetism effects of metallic debris in periprosthetic tissue. The purpose of this study is to demonstrate the diagnostic utility of these MRI-based tissue-magnetism signatures. Together with morphological MRI metrics, such as synovial volume and thickness, these measurements are utilized as biomarkers to noninvasively detect soft-tissue necrosis in symptomatic THA patients ( N=78 ). All subjects underwent an advanced MRI scan before revision surgery and tissue biopsies utilized for necrosis grading. Statistical analyses demonstrated a weak, but significant positive correlation (P = .04) between MRI magnetism signatures and necrosis scores, while indicating no meaningful association between the latter and serum cobalt and chromium ion levels. Receiver-operating characteristic (ROC) analyses were then performed based on uni- and multivariate logistic regression models utilizing the measured MRI biomarkers as predictors of severe necrosis. The area under the curve of the ROC plots for MRI biomarkers as combined predictors were found to be 0.70 and 0.84 for cross-validation and precision-recall tests, respectively.

Author List

Sherafati M, Bauer TW, Potter HG, Koff MF, Koch KM

Author

Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Anatomic Landmarks
Arthroplasty, Replacement, Hip
Feasibility Studies
Female
Hip Joint
Hip Prosthesis
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Necrosis
Postoperative Complications