Calcium-oxalate-crystal-induced bone disease. Am J Kidney Dis 1982 Mar;1(5):294-9
Date
03/01/1982Pubmed ID
7041638DOI
10.1016/s0272-6386(82)80028-0Abstract
A 13-year-old boy with primary hyperoxaluria and a successful renal allograft developed symptomatic bone disease, hypercalcemia, and hypercalciuria. Transiliac bone biopsy revealed calcium oxalate crystals in the marrow within mononuclear phagocytes and multinucleated giant cells. Deep resorption bays were seen adjacent to these crystal-cell aggregates. Serum 1,25-(OH)2-vitamin D (calcitriol) and iPTH concentrations were low or normal. We suggest that hypercalcemia results from macrophage-mediated bone resorption initiated by Ca oxalate crystal deposition.
Author List
Adams ND, Carrera GF, Johnson RP, Latorraca R, Lemann J JrMESH terms used to index this publication - Major topics in bold
AdolescentBone Diseases
Bone Resorption
Calcium Oxalate
Humans
Hypercalcemia
Kidney Transplantation
Male
Oxalates
Oxalic Acid
