Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography. Invest Ophthalmol Vis Sci 2020 Mar 09;61(3):36
Date
03/21/2020Pubmed ID
32196097Pubmed Central ID
PMC7405956DOI
10.1167/iovs.61.3.36Scopus ID
2-s2.0-85082147474 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
PURPOSE: To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism.
METHODS: Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant.
RESULTS: GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism.
CONCLUSIONS: The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.
Author List
Woertz EN, Omoba BS, Dunn TM, Chiu SJ, Farsiu S, Strul S, Summers CG, Drack AV, Carroll JAuthors
Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinErica Woertz in the CTSI department at Medical College of Wisconsin - CTSI
MESH terms used to index this publication - Major topics in bold
AdolescentAdult
Albinism, Ocular
Algorithms
Area Under Curve
Case-Control Studies
Child
Female
Humans
Image Processing, Computer-Assisted
Intraocular Pressure
Male
Nerve Fibers
Observer Variation
Retinal Ganglion Cells
Tomography, Optical Coherence
Visual Fields
Young Adult
