Faculty Collaboration Database

Hepatic free fatty acids in alcoholic liver disease and morbid obesity. Hepatology 1983;3(2):226-31

Date

03/01/1983

Pubmed ID

6832713

DOI

10.1002/hep.1840030215

Scopus ID

2-s2.0-0020665065 (requires institutional sign-in at Scopus site)   82 Citations

Abstract

Alcoholic liver disease is characterized by the accumulation of fat and inflammatory changes in the liver. Because free fatty acids, the precursors of triglycerides, can damage biological membranes, accumulation of free fatty acids in the liver might be in part responsible for the functional and morphological changes seen in alcoholic liver disease. We, therefore, determined the hepatic lipid composition in biopsies from 31 patients with alcoholic liver disease, 18 patients with morbid obesity, and 5 patients without evidence of liver disease. Free fatty acids were found in all liver biopsies. Patients with morbid obesity or alcoholic liver disease had significantly higher fatty acid and triglyceride levels than did controls (p less than 0.01). Patients with alcoholic liver disease had significantly higher fatty acid levels than did patients with morbid obesity (p less than 0.05), while there was no difference in the triglyceride concentrations between these two groups. The distribution of the fatty acids in the free fatty acid fraction differed significantly from that in the triglyceride fraction indicating a preferential incorporation of unsaturated fatty acids into triglycerides. This difference in the distribution pattern was lost in patients with the most severe forms of alcoholic liver disease. The data are consistent with the hypothesis that accumulation of free fatty acids in patients with alcoholic liver disease may be responsible for or contribute to the observed functional and morphological damages.

Author List

Mavrelis PG, Ammon HV, Gleysteen JJ, Komorowski RA, Charaf UK

Author

Helmut V. Ammon MD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Alkaline Phosphatase
Aspartate Aminotransferases
Bilirubin
Biopsy
Fatty Acids, Nonesterified
Female
Humans
Liver
Liver Diseases, Alcoholic
Male
Middle Aged
Obesity
Serum Albumin
Triglycerides