Faculty Collaboration Database

Memory Performance and Quantitative Neuroimaging Software in Mild Cognitive Impairment: A Concurrent Validity Study. J Int Neuropsychol Soc 2020 Nov;26(10):954-962

Date

04/29/2020

Pubmed ID

32340636

DOI

10.1017/S1355617720000454

Scopus ID

2-s2.0-85084404896 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

OBJECTIVE: This study examined the relationship between patient performance on multiple memory measures and regional brain volumes using an FDA-cleared quantitative volumetric analysis program - Neuroreader™.

METHOD: Ninety-two patients diagnosed with mild cognitive impairment (MCI) by a clinical neuropsychologist completed cognitive evaluations and underwent MR Neuroreader™ within 1 year of testing. Select brain regions were correlated with three widely used memory tests. Regression analyses were conducted to determine if using more than one memory measures would better predict hippocampal z-scores and to explore the added value of recognition memory to prediction models.

RESULTS: Memory performances were most strongly correlated with hippocampal volumes than other brain regions. After controlling for encoding/Immediate Recall standard scores, statistically significant correlations emerged between Delayed Recall and hippocampal volumes (rs ranging from .348 to .490). Regression analysis revealed that evaluating memory performance across multiple memory measures is a better predictor of hippocampal volume than individual memory performances. Recognition memory did not add further predictive utility to regression analyses.

CONCLUSIONS: This study provides support for use of MR Neuroreader™ hippocampal volumes as a clinically informative biomarker associated with memory performance, which is a critical diagnostic feature of MCI phenotype.

Author List

Umfleet LG, Butts AM, Janecek JK, Reiter K, Agarwal M, Brett BL, Ryan JJ, Reuss J, Klein A, Correro AN, Franczak M

Authors

Mohit Agarwal MD Associate Professor in the Radiology department at Medical College of Wisconsin
Benjamin Brett PhD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin
Alissa Butts PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Anthony N. Correro PhD Assistant Professor in the Neurology department at Medical College of Wisconsin
Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin
Julie K. Janecek PhD Associate Professor in the Neurology department at Medical College of Wisconsin
Andrew P. Klein MD Chief, Associate Professor in the Radiology department at Medical College of Wisconsin
Laura Umfleet PsyD Associate Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Brain
Cognition
Cognitive Dysfunction
Cohort Studies
Female
Hippocampus
Humans
Magnetic Resonance Imaging
Male
Memory
Memory Disorders
Neuroimaging
Neuropsychological Tests
Retrospective Studies
Software