Faculty Collaboration Database

Management of complications of androgen deprivation therapy in the older man. Crit Rev Oncol Hematol 2009 Jun;70(3):235-55

Date

10/28/2008

Pubmed ID

18952456

Pubmed Central ID

PMC3074615

DOI

10.1016/j.critrevonc.2008.09.004

Scopus ID

2-s2.0-67349141307 (requires institutional sign-in at Scopus site)   56 Citations

Abstract

Prostate cancer is the most common malignancy in older men. With the aging of the population, the number of older men with prostate cancer will grow rapidly. Androgen deprivation therapy (ADT) is the mainstay of treatment for men with systemic disease and is increasingly utilized as primary therapy or in combination with other therapies for localized disease. Side effects of therapy are multifold and include hot flashes, osteoporosis, and adverse psychological and metabolic effects. Recent research has illustrated that ADT can negatively impact the functional, cognitive, and physical performance of older men. Patients with prostate cancer, despite recurrence of the disease, have a long life expectancy and may be subjected to the side effects of ADT for many years. This review highlights the complications of ADT and approaches to management. We also provide recommendations for assessment and management of ADT complications among the most vulnerable and frail older male patients.

Author List

Mohile SG, Mustian K, Bylow K, Hall W, Dale W

Author

Kathryn A. Bylow MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Androgen Antagonists
Anemia
Antineoplastic Agents, Hormonal
Cardiovascular Diseases
Hot Flashes
Humans
Male
Metabolic Syndrome
Musculoskeletal Diseases
Osteoporosis
Prostatic Neoplasms
Quality of Life
Sexual Dysfunction, Physiological