Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism. Neurology 2004 May 11;62(9):1631-3
Date
05/12/2004Pubmed ID
15136700DOI
10.1212/01.wnl.0000125693.59817.31Abstract
The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
Author List
Seripa D, Matera MG, D'Andrea RP, Gravina C, Masullo C, Daniele A, Bizzarro A, Rinaldi M, Antuono P, Wekstein DR, Dal Forno G, Fazio VMAuthor
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAlzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Genotype
Humans
Italy
Male
Polymorphism, Single Nucleotide
Risk
Risk Factors
Tissue Banks
Wisconsin
tau Proteins