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Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism. Neurology 2004 May 11;62(9):1631-3

Date

05/12/2004

Pubmed ID

15136700

DOI

10.1212/01.wnl.0000125693.59817.31

Abstract

The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.

Author List

Seripa D, Matera MG, D'Andrea RP, Gravina C, Masullo C, Daniele A, Bizzarro A, Rinaldi M, Antuono P, Wekstein DR, Dal Forno G, Fazio VM

Author

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Genotype
Humans
Italy
Male
Polymorphism, Single Nucleotide
Risk
Risk Factors
Tissue Banks
Wisconsin
tau Proteins