Bisphosphonate-related osteonecrosis of the mandible and maxilla: clinical and imaging features. J Comput Assist Tomogr 2009;33(3):449-54
Date
05/30/2009Pubmed ID
19478642DOI
10.1097/RCT.0b013e318186b179Scopus ID
2-s2.0-67649130075 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
OBJECTIVE: Bisphosphonate-related osteonecrosis of the jaws is a rare, but morbid, condition. We present the clinical and imaging features of 19 patients.
METHODS: A review of 19 bisphosphonate-related osteonecrosis patients was performed. Patient demographics, diagnosis, dental procedures, symptoms and clinical findings, location and pattern of involvement, and presence of fractures, sequestra, and fistulae were documented.
RESULTS: Patients included 14 women and 5 men aged 48 to 80 years. Diagnoses included breast carcinoma (n = 11), multiple myeloma (n = 4), osteoporosis (n = 4), prostate carcinoma (n = 2), and lymphoma (n = 1). Seventeen patients received intravenous and 2 received oral bisphosphonates for 2 to 5 years. Bone involvement was noted in the mandible (74%), maxilla (16%), and both (10%). A lytic and sclerotic pattern was most common (58%). Additional findings included fractures (n = 5), sequestra (n = 4), and oroantral fistulae (n = 2).
CONCLUSIONS: Bisphosphonate-related osteonecrosis is a rare, but morbid, condition, and imaging features can mimic other conditions. It is important for the radiologist to consider this entity in the appropriate clinical setting.
Author List
Gill SB, Valencia MP, Sabino ML, Heideman GM, Michel MAAuthors
Sonia B. Gill MD Assistant Professor in the Radiology department at Medical College of WisconsinMichelle A. Michel MD Adjunct Professor in the Radiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Bone Density Conservation Agents
Diphosphonates
Female
Humans
Male
Mandibular Diseases
Maxillary Diseases
Middle Aged
Osteonecrosis
Radiography
