Chronic Pain Does Not Impact Baseline Circulating Cytokine Levels in Adults with Sickle Cell Disease. Acta Haematol 2021;144(1):111-116
Date
05/14/2020Pubmed ID
32403100DOI
10.1159/000507563Scopus ID
2-s2.0-85085034465 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Chronic pain affects 50% of adults with sickle cell disease (SCD). Although inflammation is thought to contribute to the pathogenesis of chronic pain, no studies have examined the differences in circulating cytokines between patients with SCD with and without chronic pain. We performed an observational cohort study using blood and urine samples from adults with SCD with and without chronic pain at their usual state of health. We tested the hypothesis that, compared to those without chronic pain, those with chronic pain would have significantly higher baseline circulating proinflammatory cytokines. A total of 61 adults with SCD, 40 with chronic pain and 21 without chronic pain were tested. When SCD patients with chronic pain were compared to those without chronic pain, no significant differences in cytokine levels were noted. The variables most associated with the diagnosis of chronic pain in this population were opioid dose and subject age.
Author List
Karafin MS, Simpson P, Field JJAuthors
Joshua J. Field MD Professor in the Medicine department at Medical College of WisconsinPippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultAnalgesics, Opioid
Anemia, Sickle Cell
Biomarkers
Chronic Pain
Comorbidity
Cytokines
Humans
Pain Management
Treatment Outcome
