Chronic administration of naltrexone alters central catecholamine levels but not the development of hypertension in spontaneously hypertensive rats. Neuropharmacology 1982 Nov;21(11):1195-8
Date
11/01/1982Pubmed ID
7177344DOI
10.1016/0028-3908(82)90179-4Scopus ID
2-s2.0-0020458158 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
The effect of chronic administration of the opiate antagonist naltrexone on the genesis and development of hypertension and correlated changes in central norepinephrine levels was evaluated in spontaneously hypertensive rats and Wistar-Kyoto controls. Capsules of poly-epsilon-caprolactone containing naltrexone in ethyl oleate or ethyl oleate alone were implanted in 4 week old SHR and WKY rats. Naltrexone failed to alter the genesis or magnitude of hypertension developed by the SHR and did not alter heart rates. Blood pressure and heart rate of WKY rats were also unaffected. A significant decrease in midbrain and hippocampal NE levels was observed in SHRs but not in WKYs following naltrexone.
Author List
Strahlendorf JC, Strahlendorf HK, McKown-Pulliam R, Hughes MJ, Lang IMAuthor
Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Brain Chemistry
Catecholamines
Heart Rate
Hypertension
Male
Naloxone
Naltrexone
Norepinephrine
Rats
Rats, Inbred Strains
Time Factors
