A Case of Congenital Anaplastic Large Cell Lymphoma in a Very Preterm Low-Birth Weight Neonate. J Pediatr Hematol Oncol 2020 Jul;42(5):e377-e380
Date
03/05/2019Pubmed ID
30830032DOI
10.1097/MPH.0000000000001450Scopus ID
2-s2.0-85062667465 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
A premature infant male was born at 30 weeks' gestation with severe coagulopathy and thrombocytopenia. Over the first days of his life, the patient developed evidence of immune hyperactivation with adenopathy, hepatosplenomegaly, and elevated ferritin. Although the patient met diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH), flow cytometric based assays were not consistent with primary HLH. A lymph node and bone marrow biopsy eventually revealed the presence of anaplastic lymphoma kinase+anaplastic large cell lymphoma. To our knowledge, this is the earliest presentation of a lymphoma, and expands the known timeframe of lymphomagenesis.
Author List
Mathanda R, Nomani L, Ondrejka S, Burdjalov V, Al-Jebwi Y, Rotz SJAuthor
Laila Nomani MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
HumansInfant, Extremely Premature
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature, Diseases
Lymphoma, Large-Cell, Anaplastic
Male
Prognosis
