Faculty Collaboration Database

Sinus tachycardia is associated with impaired exercise tolerance following heart transplantation. Clin Transplant 2017 May;31(5)

Date

03/03/2017

Pubmed ID

28251691

DOI

10.1111/ctr.12946

Scopus ID

2-s2.0-85017470047 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

BACKGROUND: Sinus tachycardia often presents in heart transplantation (HTx) recipients, but data on its effect on exercise performance are limited.

METHODS: Based on mean heart rate (HR) value 3 months after HTx, 181 patients transplanted from 2006 to 2015 at University of Nebraska Medical Center were divided into two groups: (i) HR<95 beats/min (bpm, n=93); and (ii) HR≥95 bpm (n=88). Cardiopulmonary exercise testing (CPET) was performed 1 year after HTx.

RESULTS: Mean HR at 3 months post-HTx was 94±11 bpm and did not change significantly at 1 year post-HTx (96±11 bpm, P=.13). HR≥95 bpm at 3 months was associated with younger donor age (OR 1.1; CI 1.0-1.1, P=.02), female donors (OR -2.4; CI 1.16-5.24 P=.02), and lack of donors' heavy alcohol use (OR -0.43; CI 0.17-0.61; P=.04). HR≥95 bpm at 3 months post-HTx was independently associated with decreased exercise capacity in metabolic equivalent (P=.008), reduced peak VO₂ (P=.006), and percent of predicted peak VO₂ (P=.002) during CPET.

CONCLUSIONS: HR≥95 at 3 months following HTx is associated with reduced exercise tolerance in stable HTx recipients. Medical HR reduction after HTx could improve exercise performance after HTx and merits further investigation.

Author List

Peled Y, Varnado S, Lowes BD, Zolty R, Lyden ER, Moulton MJ, Um JY, Raichlin E

Author

Eugenia Raichlin MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Exercise Tolerance
Female
Follow-Up Studies
Heart Rate
Heart Transplantation
Humans
Male
Middle Aged
Oxygen Consumption
Prognosis
Tachycardia, Sinus
Time Factors