Faculty Collaboration Database

Efficacy and safety of atrasentan in patients with cardiovascular risk and early atherosclerosis. Hypertension 2008 Sep;52(3):522-8

Date

08/13/2008

Pubmed ID

18695150

Pubmed Central ID

PMC2675066

DOI

10.1161/HYPERTENSIONAHA.108.113068

Scopus ID

2-s2.0-52049097771 (requires institutional sign-in at Scopus site)   50 Citations

Abstract

Endothelin plays an important role in the pathogenesis of atherosclerosis. The aim of the study was to evaluate the safety and hemodynamic and metabolic responses to 6 months treatment with atrasentan, the selective endothelin-A receptor antagonist. Seventy-two patients with multiple cardiovascular risk factors and nonobstructive coronary artery disease on coronary angiogram were randomly assigned in a double-blind manner to atrasentan or placebo. Mean aortic blood pressure decreased from 92+/-10 to 80+/-10 mm Hg (P<0.001) in the atrasentan group and did not change in the placebo group (93+/-10 and 92+/-11 mm Hg; P=0.84). The difference between the groups was significant (P<0.001). No effect on heart rate was observed. In a subgroup of patients not treated with angiotensin-converting enzyme inhibitor, creatinine level decreased in the atrasentan versus the placebo group (P=0.011). Fasting glucose (P=0.026), glycosylated hemoglobin level (P=0.041), triglyceride l (P=0.013), lipoprotein-A (P=0.046), and uric acid levels (P=0.048) decreased significantly in the atrasentan group compared with the placebo group. No progression of angiographic coronary disease was observed. The most common adverse effects with atrasentan were nasal stuffiness, headache, and edema. In conclusion, 6 months of treatment with atrasentan results in a reduction of blood pressure and improvement in glucose and lipid metabolism. These findings suggest the beneficial role of atrasentan in the treatment of hypertension and metabolic syndrome.

Author List

Raichlin E, Prasad A, Mathew V, Kent B, Holmes DR Jr, Pumper GM, Nelson RE, Lerman LO, Lerman A

Author

Eugenia Raichlin MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Antihypertensive Agents
Blood Glucose
Blood Pressure
Coronary Artery Disease
Edema
Endothelin A Receptor Antagonists
Endothelin-1
Female
Follow-Up Studies
Humans
Hypertension
Kidney
Lipid Metabolism
Male
Metabolic Syndrome
Middle Aged
Pyrrolidines
Receptor, Endothelin A
Risk Factors
Treatment Outcome